USMLE Step 2 CK Practice Questions

Hundreds of practice questions mapped to all clinical disciplines and organ systems on the USMLE Step 2 CK — including internal medicine, surgery, obstetrics & gynecology, pediatrics, and psychiatry. Questions include worked explanations with full solution steps.

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Sample Questions

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Question 1 of 3

A 58-year-old woman presents with 6 hours of severe, constant right upper quadrant pain, fever of 38.9 °C, and a positive Murphy sign. Labs show WBC 16,000/μL and total bilirubin 1.0 mg/dL. Ultrasound reveals a distended gallbladder with wall thickening and pericholecystic fluid. Which of the following is the most appropriate next step in management?

A Observation and serial abdominal exams
B ERCP with sphincterotomy
C IV antibiotics and early laparoscopic cholecystectomy
D HIDA scan
E Percutaneous cholecystostomy tube placement
Question 2 of 3

A 32-year-old woman, gravida 2 para 1, at 34 weeks gestation presents with a blood pressure of 162/108 mmHg, 3+ proteinuria, and a platelet count of 88,000/μL. She reports a persistent headache and right upper quadrant pain. AST is 245 U/L and LDH is 680 U/L. Which of the following is the most appropriate management?

A Oral nifedipine and outpatient follow-up in 48 hours
B IV magnesium sulfate, betamethasone, and delivery
C Expectant management with bed rest until 37 weeks
D Platelet transfusion and repeat labs in 6 hours
E IV labetalol and observation for 24 hours
Question 3 of 3

A 7-year-old boy is brought to the emergency department with a 2-day history of fever, sore throat, and rash. Examination reveals a diffuse, fine, sandpaper-like erythematous rash sparing the face, with circumoral pallor and a strawberry tongue. Rapid strep test is positive. Which of the following is the most likely diagnosis?

A Kawasaki disease
B Measles
C Scarlet fever
D Erythema infectiosum (fifth disease)
E Toxic shock syndrome

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